Effect of Vitamin B12 and folic acid supplementation on neuropsychiatric symptoms and immune response in HIV‑positive patients

Adhikari, Prabha and Chowta, Mukta N and *, John T Ramapuram and Rao, Satish BS and Udupa, Karthik and Acaharya, Sahana D (2016) Effect of Vitamin B12 and folic acid supplementation on neuropsychiatric symptoms and immune response in HIV‑positive patients. Journal of Neurosciences in Rural Practice, 7 (3). pp. 362-367. ISSN 0976-3147

[img] PDF
Journal of Neurosciences in Rural Practice.pdf - Published Version
Restricted to Registered users only

Download (1MB) | Request a copy

Abstract

Background: Micronutrients such as B12 and folic acid deficiencies are found in higher number in HIV‑infected patients. Objective: We conducted a study to examine the effect of Vitamin B12 and folic acid supplementation on neuropsychiatric manifestations, CD4 count, and anthropometric measurements in HIV‑positive patients. Materials and Methods: Three different groups of HIV patients, namely, HIV patients with tuberculosis, HIV patients with neuropsychiatric manifestations, and asymptomatic HIV patients with 50 patients in each group were included in the study. Baseline and follow‑up CD4 count, anthropometric measurements, neuropsychiatric assessments, Vitamin B12, and folic acid estimation were done. Results: The prevalence of folic acid deficiency was 27.1% in Group I, 31.9% in Group II, and 23.4% in Group III. The prevalence of Vitamin B12 deficiency was 8.16% in Group I, 6.12% in Group II, and 4.16% in Group III. HIV patients with neuropsychiatric manifestations were noted to have the lowest mean mini–mental score. After the supplementation of vitamins, anthropometric measurements, MMSE as well as Hamilton depression scores, improved in all the three groups whereas Hamilton anxiety scores improved only in Group III. The CD4 count also improved in Groups I and II after the supplementation of vitamins. Conclusion: Folic acid deficiency was highest among neuropsychiatric patients. The majority of people who had a folic acid deficiency have shown improvement in their neuropsychiatric assessment scores as well as CD4 count after its supplementation.

Item Type: Article
Uncontrolled Keywords: CD4 count, folic acid, HIV, Vitamin B12
Subjects: Medicine > KMC Mangalore > Pharmacology
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 09 Jul 2016 11:48
Last Modified: 09 Jul 2016 11:48
URI: http://eprints.manipal.edu/id/eprint/146512

Actions (login required)

View Item View Item