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Preventive Role of Vitamin E and Vitamin C In Combination on Cadmium Induced Oxidative Stress on Rat Testis.

Kini, Rekha D and *, Nayanatara AK and *, Anupama N and *, Bhagyalakshmi K and Shetty, Sneha B (2016) Preventive Role of Vitamin E and Vitamin C In Combination on Cadmium Induced Oxidative Stress on Rat Testis. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7 (4). pp. 1999-2002. ISSN 0975-8585

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Abstract

Cadmium (Cd) is an industrial pollutant that affects the male reproductive system. The purpose of present study was to investigate the protective role of vitamin E & vitamin C on cadmium induced testicular damage. Rats were divided into four groups with 8 rats in each .The Gr. I rats were administered with the single dose of normal saline intraperitoneally. Group II received Vitamin E & Vitamin C orally for 30days.Group III received a single dose of 1mg/kg bw cadmium chloride and Group IV vitamin E and vitamin C for 30 days prior to cadmium administration. After the desired protocol, rats were sacrificed & both the testes were removed for biochemical & histopathological evaluation .In the present study, the level of lipid peroxidation (LPO) was significantly high & GSH& SOD were low in cadmium treated rats compared to normal control. Pre-treatment with vitamin E & C showed a protective effect by decreasing LPO & increasing GSH& SOD level. The morphological changes like atrophy of tubules, edema &decreased spermatogenesis in the testis of rats exposed to cadmium chloride. But, antioxidant showed the normal architecture of the testis .Thus, present study showed that pre-treatment with vitamin E & C combination was beneficial in protecting the testis from cadmium induced toxicity

Item Type: Article
Uncontrolled Keywords: Cadmium, oxidative stress, antioxidants, lipid peroxide, glutathione
Subjects: Medicine > KMC Mangalore > Physiology
Depositing User: KMCMLR User
Date Deposited: 12 Jul 2016 14:49
Last Modified: 12 Jul 2016 14:49
URI: http://eprints.manipal.edu/id/eprint/146564

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