Topical use of Jatyadi Oil in normal and dexamethasone suppressed wound healing in animal studies

Babykutty, Sherin and Jose, Sumisha and Shenoy, Rekha R (2016) Topical use of Jatyadi Oil in normal and dexamethasone suppressed wound healing in animal studies. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7 (4). pp. 669-677. ISSN 0975-8585

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Abstract

The present study was undertaken to appraise the topical effects of Jatyadi Taila [JT] on normal and dexamethasone (DEX) suppressed wound healing in albino Wistar rats. Incision and excision wounds were experimentally induced in the animals. Topical application of JT on normal incision wound caused a significant (p<0.05) increase in wound breaking strength when compared to control and DEX treated animals. JT significantly (p<0.05) improved tensile strength in JT+DEX treated group as compared to DEX group. A significant (p<0.01) rise in hydroxyproline levels were exhibited in JT+DEX treatment as compared to normal and DEX control. JT reversed the DEX suppressed inflammation which was evident from the histo-pathological studies showing increased neutrophils and macrophage infiltration. Dense collagen deposition and high fibroblast counts were observed in the photomicrograph sections of JT+DEX treated group. The present study suggests the substantial potential of JT in wound management in both normal and delayed healing.

Item Type: Article
Uncontrolled Keywords: Jatyadi oil; dexamethasone; HillSlope; hydroxyproline; anti-oxidants.
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 28 Jul 2016 09:20
Last Modified: 28 Jul 2016 09:20
URI: http://eprints.manipal.edu/id/eprint/146703

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