Janardhanan, M and Nayak, V and Thomas, J and Bairy, KL (2016) A Study to Evaluate the Safety of Rapid and Conventional Rituximab Infusion in a Tertiary Care Centre. International Journal of Toxicological and Pharmacological Research, 8 (4). pp. 237-242. ISSN 0975-5160

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Abstract

Antibody-based therapy, in particular rituximab, is a promising strategy in the treatment of Non-Hodgkin lymphoma. Rituximab chemotherapy combinations have revolutionised the treatment outcomes in NHL. A major barrier to effective treatment of rituximab is the lengthy infusion time. Hence, by reducing the chair time of one patient from the conventional 4-6 hours to rapid (90 minutes) infusion, more number of patients can be accommodated in outpatient facility. A total of 40 patients who received rapid infusion of rituximab over 90 minutes and 30 patients who received conventional infusion were evaluated for the safety parameter. It was observed that rapid infusion was well tolerated with no grade 3 or 4 reaction and there was no significant difference in the safety analysis between the rapid and conventional infusion. Therefore, it can be concluded that rapid infusion of rituximab can be opted as a safer alternative to conventional infusion and also improves patient satisfaction

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