Her-2 Gene, Receptors And Drug Target: A Systematic Review

Holla, Sadhana N and Nayak, Veena and Bairy, KL and Tripathy, Amrutha (2016) Her-2 Gene, Receptors And Drug Target: A Systematic Review. International Journal of Pharmacy and Pharmaceutical Sciences, 8 (4). pp. 4-9. ISSN 0975-1491

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The discovery and identification of the human epidermal growth factor receptor 2 (HER’s-2) genes, have led to a better understanding of breast tumour biology. A member of the epidermal growth factor receptor family, it is a potent mediator of cellular growth and proliferation in malignant epithelial cells. Amplification or over expression of HER-2 occurs in approximately 15–30 % of breast cancers and 10–30 % of gastric/gastroesophageal cancers and serves as a prognostic and predictive biomarker. Treatment with HER-2 targeted monoclonal antibody,trastuzumab dramatically improved outcome in patients with breast malignancy. This promising approach led to the development of pertuzumab,ado-trastuzumab emtansine and lapatinib. The development of drug resistance and disease progression due to alternate signalling remained a real therapeutic challenge. Several research studies are currently focused on inhibition of onco-proteins, kinases and growth factors linked to HER-2 positive breast cancers. The success of immune checkpoint modulators and vaccines in preliminary studies describes the role of tumour immunity.Apart from its role in the pathogenesis of various cancers, HER-2 directed therapeutic approach has brought about a revolutionary change in terms of time to progression and survival rates in breast cancers.

Item Type: Article
Uncontrolled Keywords: ErbB-2 signalling; Targeted approach; Trastuzumab; Drug resistance
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 04 Oct 2016 14:20
Last Modified: 04 Oct 2016 14:20
URI: http://eprints.manipal.edu/id/eprint/146934

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