Rifampicin-Induced concomitant renal injury and hepatitis

Chogtu, Bharti and Vyshak, US and Magazine, Rahul and Yerrapragada, Devesh Bhaskar (2016) Rifampicin-Induced concomitant renal injury and hepatitis. Journal of Clinical and Diagnostic Research, 10 (9). OD18-OD19. ISSN 0973-709X

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Abstract

Adverse drug reactions are not unusual during Anti-Tubercular Therapy (ATT). One of the common complications of anti-tubercular treatment is drug induced hepatitis and renal insufficiency has also been reported. Renal failure and/or hepatitis encountered during treatment of tuberculosis can have varied aetiologies: drug induced, concomitant viral infection, pre-existing co-morbidities or a combination of these. Since, hepatitis and/or renal insufficiency can be life threatening a prompt diagnosis is warranted, where drugs should be kept as one of the important cause. Identifying the drug helps in treating hepatitis and/or renal insufficiency along with helping the physician to change the combination of ATT regimen. Rifampicin is one of the most important first line drugs in the treatment of tuberculosis. Hepatitis, epigastric distress, anaemia, thrombocytopenia, and interstitial nephritis are reported adverse drug reactions to rifampicin. As per literature rifampicin induced renal toxicity is usually seen on rifampicin re-exposure, or rifampicin administration on alternate days, both being present in this case. Here we are reporting a case of ATT induced renal failure with concomitant hepatitis where rifampicin was suspected to be the cause.

Item Type: Article
Uncontrolled Keywords: Anti tubercular drugs; Liver function tests; Serum creatinine; Serum urea.
Subjects: Medicine > KMC Manipal > Pharmacology
Medicine > KMC Manipal > Pulmonary Medicine
Depositing User: KMC Library
Date Deposited: 26 Sep 2016 10:47
Last Modified: 26 Sep 2016 10:47
URI: http://eprints.manipal.edu/id/eprint/147022

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