Effect of ocimum sanctum linn. Leaf extract on wound healing in streptozotocin induced diabetic rats

Shetty, Somashekar B (2016) Effect of ocimum sanctum linn. Leaf extract on wound healing in streptozotocin induced diabetic rats. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7 (5). pp. 845-850. ISSN 0975-8585

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Abstract

The medicinal plants are widely used by the traditional medicinal practitioners for curing various diseases in their day to day practice. The plant O.sanctum is used in traditional medicine to treat a variety of disorders. The objective of this study presented in this report was to evaluate the wound healing potential of ethanolic extract of the plant in streptozotocin-induced diabetic rats. The study was carried out by using Wistar albino rats by creating excision and dead space wounds. The measured wound area of the O.sanctum treated group was reduced significantly when compared to diabetic control animals. Significant increase in the weight of the granulation tissue and the hydroxyproline content were observed. The fasting blood glucose values of the diabetic experimental group animals were significantly reduced when compared to the controls We noticed the correlation between the wound contraction rate and the blood glucose values. The results of the present study clearly demonstrate that the ethanolic extract of O. sanctum has a definite prohealing action in normal healing as well as in the diabetes induced wound healing.

Item Type: Article
Uncontrolled Keywords: Wound healing; Sterptozotocin; Diabetes; O; sanctum.
Subjects: Medicine > MMMC Manipal > Biochemistry
Depositing User: KMC Library
Date Deposited: 28 Sep 2016 14:33
Last Modified: 28 Sep 2016 14:33
URI: http://eprints.manipal.edu/id/eprint/147040

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