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Tumour Budding: A Promising Parameter in Oral Squamous Cell Carcinoma.

*, Nandita KP and Boaz, Karen and *, Srikant N and Lewis, Amitha J and Manaktala, Nidhi (2016) Tumour Budding: A Promising Parameter in Oral Squamous Cell Carcinoma. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7 (5). pp. 2059-2063. ISSN 0975-8585

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Abstract

Oral squamous cell carcinoma (OSCC), the fifth most common cancer worldwide. The major risk factor for this neoplasm is chronic exposure of oral mucosa to tobacco and alcohol. The presence of tumour budding at the invasive front (IF) has been reported as a promising prognosticator in OSCC. Tumour budding is defined as isolated single cancer cell or a cluster of cancer cells composed of fewer than five cells. The study aimed to identify the characteristics of tumour budding in prognostication of OSCC. Thirty histological specimens of biopsy proven OSCC were considered in this study. Serial sections of 4 um thickness were taken and stained. Cancer cells were observed in cancer-stroma lesions at the invasive front of the tumour. Number of tumour budding foci were counted in the histological fields in which the tumour budding intensity was maximal. Independent t test was used for comparing tumour budding with prognostic parameters on the basis value p value < 0.05 which was considered as statistically significant. The degree of tumour budding was linked with poor tumour differentiation. Presence of tumour budding foci is a significant indicator to predict the prognosis in Oral cancer patients.

Item Type: Article
Uncontrolled Keywords: Tumour budding, Oral squamous cell carcinoma, Invasive front
Subjects: Dentistry > MCODS Mangalore > Oral Pathology
Depositing User: KMCMLR User
Date Deposited: 28 Sep 2016 14:19
Last Modified: 28 Sep 2016 14:19
URI: http://eprints.manipal.edu/id/eprint/147047

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