The Antibiotics of Choice for the Treatment of Melioidosis in Indian Set Up

Shaw, Tushar and Tellapragada, Chaitanya and Eshwara, Vandana Kalwaje and Bhat, Vinod H and Mukhopadhyay, Chiranjay (2016) The Antibiotics of Choice for the Treatment of Melioidosis in Indian Set Up. Indian Journal of Medical Microbiology, 34 (3). pp. 353-354. ISSN 0255-0857

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Therapeutic options for the treatment of melioidosis caused by Burkholderia pseudomallei are limited due to the inherent resistance conferred by this pathogen to various groups of antibiotics. Witnessing an increase in the number of microbiological culture‑confirmed cases of melioidosis at our settings in the past few years, we undertook this study to estimate the minimum inhibitory concentrations of clinical isolates of B. pseudomallei against the four commonly employed antimicrobial agents in the patient management at our settings, namely, ceftazidime, meropenem, trimethoprim‑sulfamethoxazole and doxycycline. All isolates were susceptible to the antibiotics tested, except for one isolate which showed resistance to doxycycline (minimum inhibitory concentration [MIC]: 32 µg/ml). MIC50 and 90 for all the four antibiotics were estimated. From this study, we conclude that the clinical isolates of B. pseudomallei from the southern part of India are well susceptible to the commonly employed antimicrobial agents for therapy.

Item Type: Article
Uncontrolled Keywords: Burkholderia pseudomallei; Melioidosis; Minimum inhibitory concentration
Subjects: Medicine > KMC Manipal > Community Medicine
Departments at MU > Manipal Centre for Virus Research
Medicine > KMC Manipal > Microbiology
Depositing User: KMC Library
Date Deposited: 07 Oct 2016 15:35
Last Modified: 07 Oct 2016 15:35

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