Angiogenesis in Cutaneous Lesions of Leprosy

Bhandarkar, Sulochana S and Cohen, Cynthia and Kuruvila, Maria and Thomas, Rea H. and MacKelfresh, Jamie B. and *, Delphine J. Lee and *, Robert L. Modlin and *, Jack L. Arbiser (2007) Angiogenesis in Cutaneous Lesions of Leprosy. Arch Dermatol, 143 (12). pp. 1527-1529.

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Objective: To examine the potential role of angiogenesis in leprosy. Design: Immunohistochemical analysis of leprosy lesions. Setting: Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University. Patients: Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients. Main Outcome Measure: CD31 microvessel counts. Results: The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions. Conclusions: Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.

Item Type: Article
Subjects: Medicine > KMC Mangalore > Dermatology
Depositing User: KMCMLR User
Date Deposited: 17 Oct 2016 14:42
Last Modified: 17 Oct 2016 14:42

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