Caffeic Acid Attenuates Lipopolysaccharide-induced Sickness Behaviour and Neuroinflammation in Mice

Mallik, Sanchari Basu and Mudgal, Jayesh and Nampoothiri, Madhavan and Rao, Mallikarjuna C and Arora, Devinder (2016) Caffeic Acid Attenuates Lipopolysaccharide-induced Sickness Behaviour and Neuroinflammation in Mice. Neuroscience Letters, 632. pp. 218-223.

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Abstract

Accumulating data links inflammation, oxidative stress and immune system in the pathophysiology of major depressive disorders. Sickness behaviour is a set of behavioural changes that develop during infection, eventually leading to decrease in mobility and depressed behaviour. Lipopolysaccharide (LPS) induces a depression-like state in animals that mimics sickness behaviour. Caffeic acid, a naturally occurring polyphenol, possesses antioxidant and anti-inflammatory properties. The present study was designed to explore the potential of caffeic acid against LPS-induced sickness behaviour in mice. Caffeic acid (30 mg/kg) and imipramine (15 mg/kg) were administered orally one hour prior to LPS (1.5 mg/kg) challenge. Behavioural assessment was carried out between 1 and 2 h and blood samples were collected at 3 h post-LPS injection. Additionally, cytokines (brain and serum) and brain oxidative stress markers were estimated. LPS increased the systemic and brain cytokine levels, altered the anti-oxidant defence and produced key signs of sickness behaviour in animals. Caffeic acid treatment significantly reduced the LPS-induced changes, including reduced expression of inflammatory markers in serum and whole brain. Caffeic acid also exerted an anti-oxidant effect, which was evident from the decreased levels of oxidative stress markers in whole brain. Our data suggests that caffeic acid can prevent the neuroinflammation-induced acute and probably the long term neurodegenerative changes.

Item Type: Article
Uncontrolled Keywords: Caffeic acid; Sickness behaviour; Neuroinflammation; Cytokines; Anti-oxidant
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 22 Oct 2016 08:47
Last Modified: 22 Oct 2016 08:47
URI: http://eprints.manipal.edu/id/eprint/147354

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