Analysis of the distribution of mucins in adult human gastric mucosa and its functional significance

Prasanna, LC (2016) Analysis of the distribution of mucins in adult human gastric mucosa and its functional significance. Journal of Clinical and Diagnostic Research, 10 (2). AC01-AC04. ISSN 0973-709X

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Abstract

Introduction: Mucins are complex composition of carbohydrates seen in the epithelial cells lining the gastrointestinal tract (GIT). Normal distribution of such mucins in different part of the GIT and its alteration in various inflammatory, benign and malignant lesions of GIT has aroused interest in the field of histochemistry. Aim: By applying variety of histochemical techniques an attempt has been made to draw a map of mucin secretion by the different epithelial cell types in different parts of the stomach. Materials and Methods: Fifty samples were taken each from different parts of the stomach like fundus, body and pylorus, from dissected fresh specimens (total of 150 specimens). Tissue samples were subjected for routine process and studied for histological and different histochemical staining. Results: Mucin pattern in adult predominantly secretes neutral mucosubstances. Surface epithelium shows predominant neutral mucin while cardiac and gastric glands with foveolar cells show moderate amount. Sialomucin is present in a few cells of the surface epithelium, foveolar cells and in most of the mucous neck cells. Small amount of sialomucin and sulphomucin are found in surface epithelial foveolar cells while traces of sulphomucin are found in deep foveolar cells. Mucous neck cells secrete both sulphomucin and sialomucin. Conclusion: Normal gastric mucosa adjacent to gastric ulcers and malignant tumours of stomach secretes mucins which differ histochemically and biochemically from that of normal. Early recognition of such changes could be useful in recognizing the different type of carcinomas and their prognosis.

Item Type: Article
Uncontrolled Keywords: Foveolar cells; gastric glands; histochemistry; mucosubstances.
Subjects: Medicine > KMC Manipal > Anatomy
Depositing User: KMC Library
Date Deposited: 25 Oct 2016 13:53
Last Modified: 25 Oct 2016 13:53
URI: http://eprints.manipal.edu/id/eprint/147402

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