Glaucoma and its Association with Obstructive Sleep Apnea: A Narrative Review

Aditya, Chaitanya and Pai, Vijaya H and Mohapatra, Aswini Kumar and Ramesh, S Ve (2016) Glaucoma and its Association with Obstructive Sleep Apnea: A Narrative Review. Oman Journal of Ophthalmology, 9 (3). pp. 125-134. ISSN 0974-620X

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Abstract

Obstructive sleep apnea (OSA) is one of the systemic risk factors for glaucoma which causes irreversible visual field (VF) damage. We reviewed the published data of all types of studies on the association between these two conditions and papers regarding functional and structural changes related to glaucomatous damage using Scopus, web of science, and PubMed databases.There is evidence that the prevalence of glaucoma is higher in OSA patients, which independent of intraocular pressure (IOP). Studies have reported thinning of retinal nerve fiber layer (RNFL), alteration of optic nerve head, choroidal and macular thickness, and reduced VF sensitivity in patients of OSA with no history glaucoma. A negative correlation of apnea–hypopnea index with RNFL and VF indices has been described in some studies. Raised IOP was noted which is possibly related to obesity, supine position during sleep, and raised intracranial pressure. Diurnal fluctuations of IOP show more variations in OSA patients before and after continuous positive airway pressure (CPAP) therapy when compared with the normal cases. The vascular factors behind the pathogenesis include recurrent hypoxia with increased vascular resistance, oxidative stress damage to the optic nerve. In conclusion, comprehensive glaucoma evaluation should be recommended in patients with OSA and should also periodically monitor IOP during CPAP treatment which may trigger the progression of glaucomatous damage.

Item Type: Article
Uncontrolled Keywords: Choroidal thickness; Glaucoma; Intraocular pressure; Macular thickness; Obstructive sleep apnea; Retinal nerve fiber layer; Visual fields
Subjects: Allied Health > MCOAHS Manipal > Optometry
Medicine > KMC Manipal > Ophthalmology
Medicine > KMC Manipal > Pulmonary Medicine
Depositing User: KMC Library
Date Deposited: 28 Oct 2016 09:19
Last Modified: 28 Oct 2016 09:19
URI: http://eprints.manipal.edu/id/eprint/147439

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