Shetty, Nitinkumar S and Nadafy, F and Bilehal, Dinesh and Shyamkumar, V and Gaonkar, Santosh L (2016) Synthesis, Characterization and Single Crystal Studies of 3-cyclopropyl-3, 4-dihydroquinazolin-2(1H)-one. Oriental Journal of Chemistry, 32 (5). pp. 2707-2712. ISSN 0970-020X

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Abstract

The paper describes industrially scalable synthesis and single crystal studies of cyclopropyl-3, 4-dihydroquinazolin-2(1H)-one 4, a versatile intermediate in the synthesis of number of biologically active compounds. The target compound has been characterized by LC-MS, 1H NMR and IR. The crystal structure analysis shows that the title compound crystallizes in monoclinic class under the space group P 1 21/n 1 with cell parameters, a = 10.273(2) Å, b = 8.3227(19) Å, c = 11.623(3) Å, β = 104.980(3)°, V = 960.0(4) Å3 and Z=4.

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