Extraction, Characterization and Evaluation of Kaempferia Galanga L.(Zingiberaceae) Rhizome Extracts Against Acute and Chronic Inflammation in Rats

Puralae, Channabasavaiah Jagadisha and Mudgal, Jayesh and Kutty, Gopalan N (2016) Extraction, Characterization and Evaluation of Kaempferia Galanga L.(Zingiberaceae) Rhizome Extracts Against Acute and Chronic Inflammation in Rats. Journal of Ethnopharmacology, 194. pp. 434-439. ISSN 0378-8741

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Abstract

Ethnopharmacological relevance: The rhizomes of an acaulescent perennial herb, Kaempferia galanga Linn (Family: Zingiberaceae), used as traditional ayurvedic herb to get relief from indigestion, swelling, pain, high blood pressure and dyslipidemia.Aim of the study: To prepare and characterize various extracts of Kaempferia galanga (K. galanga) for their comparative evaluation for the identification of the most efficacious extract and its possible pharmacological implication in acute and chronic inflammatory paradigm.Materials and methods: Dried and powdered rhizome of K. galanga was subjected to alcoholic extraction as well as successive extractions with various solvents. After phytochemical characterization, all the extracts were standardized for the presence of ethyl-p-methoxycinnamate. The extracts, and the isolated compound, were tested against carrageenan-induced acute inflammation in rats. The most promising extract was tested against adjuvant- induced chronic inflammation in rats. Further, local myeloperoxidase (MPO) levels were investigated to establish the possible mechanism of action.Results: Among the extracts, petroleum ether extract (SKG-1) and crude alcoholic extract (KG) had the maximum quantity of ethyl-p-methoxycinnamate. SKG-1 (300 mg/kg) was found effective against acute inflammation in rats. Further, SKG-1 (100 mg/kg) reversed the inflammation and elevated MPO levels found in the chronic model.Conclusions: The results suggest that among all the extracts of K. galanga, SKG-1 effectively suppresses the progression of acute and chronic inflammation in rats by inhibition of neutrophil infiltration.

Item Type: Article
Uncontrolled Keywords: aempferia galanga L; Rhizomes; Inflammation; Adjuvant; Myeloperoxidase
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 07 Nov 2016 08:45
Last Modified: 07 Nov 2016 08:45
URI: http://eprints.manipal.edu/id/eprint/147471

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