Polycaprolactone-based in situ implant containing curcumin-PLGA nanoparticles prepared using the multivariate technique

Kasinathan, Narayanan and Amirthalingam, Muthukumar and Reddy, Neetinkumar D and Vanthi, Meenashi B and Volety, Subrahmanyam Mallikarjuna and Rao, Josyula Venkata (2016) Polycaprolactone-based in situ implant containing curcumin-PLGA nanoparticles prepared using the multivariate technique. Artificial Cells, Nanomedicine, and Biotechnology, 44 (6). pp. 1520-1528. ISSN 2169-1401

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Abstract

Studies on the eff ect of curcumin/PLGA ratio (CPR), stabilizer (PVA) concentration, homogenization speed, homogenization time, and sonication time on mean particle size (MPS) and percentage drug encapsulation (PDE) were performed using the multivariate technique. MPS and PDE were found to be more dependent on the interaction of sonication time with the other variables. Curcumin was released in a sustained manner from curcumin-PLGA nanoparticles (CPN). CPN improved the survival rate of Ehrlich ascites carcinoma (EAC)-bearing mice and controlled the EAC-induced change in hematological parameters. Histopathology of vital organs showed that the formulation was safe. Polycaprolactone was used in preparing an in situ implant containing CPN.

Item Type: Article
Uncontrolled Keywords: Box – Behnken design; design of experiment; Ehrlich ascites carcinoma; experimental design; factorial design; quality by design.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 19 Nov 2016 09:34
Last Modified: 19 Nov 2016 09:34
URI: http://eprints.manipal.edu/id/eprint/147554

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