Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences

Vuda, Madhusudanarao and Kamath, Ashwin (2016) Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences. Mitochondrion, 31. pp. 63-74. ISSN 15677249

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Abstract

Several commonly usedmedications impair mitochondrial function resulting in adverse effects or toxicities. Drug inducedmitochondrial dysfunctionmay be a consequence of increased production of reactive oxygen species, alteredmitochondrial permeability transition, impaired mitochondrial respiration, mitochondrial DNA damage or inhibition of beta-oxidation of fatty acids. The clinical manifestation depends on the specific drug and its effect on mitochondria. Given the ubiquitous presence of mitochondria and its central role in cellular metabolism, drugmitochondrial interactions may manifest clinically as hepatotoxicity, enteropathy, myelosuppression, lipodystrophy syndrome or neuropsychiatric adverse effects, to name a few. The current review focuses on specific drug groups which adversely affect mitochondria, the mechanisms involved and the clinical consequences based on the data available from experimental and clinical studies. Knowledge of these adverse drug-mitochondrial interactionsmay help the clinicians foresee potential issues in individual patients, prevent adverse drug reactions or alter drug regimens to enhance patient safety.

Item Type: Article
Uncontrolled Keywords: Adverse drug reaction; Drug; Mitochondrion; Cell death
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 30 Nov 2016 09:43
Last Modified: 30 Nov 2016 09:43
URI: http://eprints.manipal.edu/id/eprint/147628

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