Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case

Avinash, A and Amberkar, Mohan Babu V and Kunder, Sushil Kiran and Madhyastha, Sampath and Meena Kumari, K (2016) Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case. Journal of Clinical and Diagnostic Research, 10 (12). pp. 1-3. ISSN 0973-709X

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Abstract

Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and carbamazepine are commonly implicated. Agranulocytosis is the existence of a clinically significant reduction in neutrophil count.This condition is a serious threat to the patient, as he/she is at a greater risk of contracting bacterial or fungal infections, which may prove to be fatal. The co-existence of Stevens-Johnson syndrome and agranulocytosis in the same patient further increases the risk of morbidity and mortality. To the best of our knowledge, there are no reports available in the existing literature, of cases that were reported with both these life-threatening conditions in a single patient, at the same point of time. This is a case narrative of a patient who presented with both Stevens-Johnson syndrome and agranulocytosis, following the administration of carbamazepine The patient’s differential leucocyte count revealed a neutrophil proportion of 2.33%. A causality assessment done using Naranjo’s algorithm showed that carbamazepine “definitely” caused Agranulocytosis and “probably” caused Stevens-Johnson Syndrome.

Item Type: Article
Uncontrolled Keywords: Anticonvulsant; Antiepileptic; Hypersensitivity; Rash; Skin
Subjects: Medicine > KMC Manipal > Medicine
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 08 Dec 2016 09:17
Last Modified: 08 Dec 2016 09:17
URI: http://eprints.manipal.edu/id/eprint/147674

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