Clinico-microbiological study of Pseudomonas aeruginosa in wound infections and the detection of metallo-β-lactamase production

Bangera, Divya and Shenoy, Suchitra M and Saldanha, Dominic RM (2016) Clinico-microbiological study of Pseudomonas aeruginosa in wound infections and the detection of metallo-β-lactamase production. International Wound Journal, 13 (12). pp. 1299-1302. ISSN 1742-4801

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Abstract

Pseudomonas aeruginosa is a common opportunistic pathogen of humans among the Gram-negative bacilli. Clinically, it is associated with nosocomial infections like burns and surgical-site wound infections and remains a major health concern, especially among critically ill and immunocompromised patients. This is a prospective laboratory-based 2 year study conducted to isolate P. aeruginosa from wound specimens and the antimicrobial susceptibility pattern with reference to metallo-β-lactamase (MBL) production. Two hundred and twenty-four samples of P. aeruginosa isolated from wound specimens were included in the study. Antimicrobial susceptibility was done as per Clinical Laboratory Standard Institute (CLSI) guidelines. MBL-producing P. aeruginosa was detected using the EDTA disk diffusion synergy test. Statistical analysis was done using the SPSS 11 package (SPSS Inc., Chicago, IL). Out of the 224 P. aeruginosa isolates, 100% were susceptible to polymyxin B and colistin, 92⋅8% were sensitive to imipenem, 38% showed resistance to gentamicin followed by ceftazidime (31⋅69%) and meropenem (33⋅03). Sixteen (7⋅14%) isolates showed MBL production. Infection caused by drug-resistant P. aeruginosa is important to identify as it poses a therapeutic problem and is also a serious concern for infection control management. The acquired resistance genes can be horizontally transferred to other pathogens or commensals if aseptic procedures are not followed

Item Type: Article
Uncontrolled Keywords: Metallo beta lactamase; Multidrug resistance; Nosocomial; Pseudomonas aeruginosa; Wound infection
Subjects: Medicine > KMC Mangalore > Microbiology
Depositing User: KMCMLR User
Date Deposited: 09 Dec 2016 14:58
Last Modified: 09 Dec 2016 14:58
URI: http://eprints.manipal.edu/id/eprint/147686

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