Methotrexate Induced Pancytopenia - An Unwanted Effect

Singh, Brij Mohan Kumar and Banerjee, Barnini (2016) Methotrexate Induced Pancytopenia - An Unwanted Effect. International Journal of Health Sciences and Research, 6 (5). pp. 412-415. ISSN 2249-9571

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Abstract

Rheumatoid arthritis (RA) is a chronic, progressive multisystemic inflammatory disorder which affects approximately 0.5-1% of adult population. [1] Usually middle aged adult males are involved more than the females. This chronic inflammatory disorder results in the damage of articular cartilage with repeated attacks. Many a times the involvement is very symmetrical affecting both large and small joints. Thus, it is very important to introduce the effective treatment to inhibit the inflammation and destructive mechanisms as soon as the disease is diagnosed. Among the current management scheme of rheumatoid arthritis, Methotrexate (MTX) is the commonest disease-modifying ant rheumatic drug (DMARD). [2] Most of the time MTX is prescribed as monotherapy and also in combination with other DMARDs. The patients who are on long term treatment of RA are at great risk for the development of hematological toxicity, which includes leucopenia, thrombocytopenia, megaloblastic anaemia and pancytopenia, and their prevalence is estimated to be 3%. [3] The dreaded effect such as pancytopenia, which is a serious and unpredictable adverse effect of low-dose MTX, may be underestimated and sometimes results to be fatal for the patients. We report a case of severe bone marrow suppression in a rheumatoid arthritis patient on accidental intake of large dose of MTX.

Item Type: Article
Uncontrolled Keywords: Rheumatoid arthritis; DMARD; Bone marrow suppression
Subjects: Medicine > KMC Manipal > Immunohematology and Blood Transfusion
Medicine > KMC Manipal > Microbiology
Depositing User: KMC Library
Date Deposited: 15 Dec 2016 14:42
Last Modified: 15 Dec 2016 14:42
URI: http://eprints.manipal.edu/id/eprint/147727

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