Evaluation of Ischemia-Modified Albumin, Malondialdehyde, and Advanced Oxidative Protein Products as Markers of Vascular Injury in Diabetic Nephropathy

Ahmad, Afzal and Manjrekar, Poornima and Yadav, Charu and Agarwal, Ashish and *, Rukmini M S and Hegde, Anupama (2016) Evaluation of Ischemia-Modified Albumin, Malondialdehyde, and Advanced Oxidative Protein Products as Markers of Vascular Injury in Diabetic Nephropathy. Biomarker Insights, 11 (5). pp. 63-68. ISSN 11772719

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Abstract

Aim: This study aimed at evaluation of ischemia-modified albumin (IMA), malondialdehyde (MDA), and advanced oxidative protein products (AOPP) as markers of vascular injury in diabetic nephropathy (DN) with derivation of cutoff values for the same. Ma teria ls and methods: Study population comprised 60 diabetes patients and 30 controls, with diabetes patients further categorized into three groups based on urine albumin/creatinine ratio (UACR) of ,30 mg/g (diabetes without microalbuminuria), 30–300 mg/g (early DN), and .300 mg/g of creatinine (overt DN). Serum IMA, MDA, and AOPP were estimated by enzyme-linked immunosorbent assay; HbA1c, serum creatinine, urine albumin, and urine creatinine were estimated using automated analyzers. Statistical analysis was done using analysis of variance, Pearson’s correlation coefficient, and receiver-operating characteristic curve. Results: A statistically significant difference was found in the levels of IMA among patients with early DN (154 ng/mL), diabetes without nephropathy (109.4 ng/mL), and healthy controls (45.7 ng/mL), with highest levels in early DN cases. Similar increase was seen in AOPP as well. A significant correlation was observed between IMA and UACR in diabetes without nephropathy (r = 0.448). Conclusion: The present study postulates serum IMA as a novel biomarker for the assessment of disease progression in diabetes even before microalbuminuria, and a cutoff point $99 ng/mL can be used for detection of early DN.

Item Type: Article
Uncontrolled Keywords: Advanced oxidative protein products, diabetic nephropathy, ischemia-modified albumin, malondialdehyde, vascular injury
Subjects: Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 08 Jan 2018 05:59
Last Modified: 08 Jan 2018 05:59
URI: http://eprints.manipal.edu/id/eprint/147758

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