Predominance and influence of vitamin d deficiency on glycemic and lipid indices in type 2 diabetes subjects: a case control study

*, Yalla Durgarao and Manjrekar, Poornima and Adhikari, Prabha and *, Arun S and *, Chakrapani M and *, Rukmini M S (2017) Predominance and influence of vitamin d deficiency on glycemic and lipid indices in type 2 diabetes subjects: a case control study. Asian Journal of Pharmaceutical and Clinical Research, 10 (4). pp. 177-180. ISSN 0974-2441

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Abstract

Objective: To investigate the existence of vitamin D deficiency (VDD) among Type 2 diabetes, nondiabetes individuals and its effect on both glycemic and lipid profiles. Methods: A case-control study was conducted on 200 subjects of both genders (100 Type 2 diabetes and 100 nondiabetes individuals) aged 40-60 years. Fasting serum 25-hydroxycholecalciferol (25(OH) D) levels, fasting blood sugar (FBS), hemoglobin A1c (HbA1c), lipid profile including total cholesterol (TC), triglycerides (TGs), high density lipoprotein (HDL), low density lipoprotein (LDL), TC/HDL, and very LDL were estimated. Atherogenic index of plasma (AIP) was calculated. Group comparisons were done by one-way analysis of variance followed by post-hoc Tukey’s test and Student’s independent t-test. Chi-square test was performed for categorical variables. Correlation was done by Pearson’s analysis. p<0.05 was considered significant. Results: The average serum 25(OH) D levels were significantly (p<0.001) low in diabetes group. The prevalence of VDD and the percentage of insufficient and sufficient categories was significantly (p<0.001) high and low, respectively, in diabetes group. In the deficient category, diabetes group had severe VDD with significantly low-HDL and elevated TGs and there was an insignificant but negative association between serum vitamin D levels, FBS, HbA1c, TC, TG, LDL, TC/HDL, and AIP among diabetes patients. Conclusion: The occurrence of severe VDD coupled with the independent association of the same with the glycemic and lipid profiles in Type 2 diabetes may further add to the aggravation of complications

Item Type: Article
Uncontrolled Keywords: Vitamin D deficiency, Type 2 diabetes, Glycemic and lipid indices.
Subjects: Medicine > KMC Mangalore > Biochemistry
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 08 Jan 2018 05:59
Last Modified: 08 Jan 2018 05:59
URI: http://eprints.manipal.edu/id/eprint/147764

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