Lysophosphatidic acid converts monocytes into macrophages in both mice and humans

Ray, Rashmi and Rai, Vivek (2017) Lysophosphatidic acid converts monocytes into macrophages in both mice and humans. Blood, 129 (9). pp. 1177-1183. ISSN 0006-4971

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Abstract

Monocytes andmacrophages represent criticalarmsof the innateimmune systemandare considered regulators and effectors of inflammation and the innate immune response. Monocytes can mobilize from bone marrow, traffic to their required destination, and differentiate into effector cells, depending on the local tissue environment, to perform multiple roles during infection or inflammation, making them important components of body’s immune defense. Macrophages have diverse roles in tissue homeostasis, development, and tissue repair following injury. Adult bone marrow monocytes can give rise to tissue-resident macrophages during infection or inflammatory reactions, besides self-replication of tissue resident macrophages. Lysophosphatidic acid (LPA), a lipid byproduct of autotaxin activity, is involved in cancer, vascular defects, and neural tissue, but is largely unexplored in immune system. Here, we reveal an unexpected function of LPA that transfigures CD11b1 murine monocytes into F4/801 macrophages. LPA-stimulated Akt/mTOR signaling is critical for LPA-mediated macrophage development in mice. Additionally, transcriptome analysis reveals that PPARg is the key transcriptional regulator in the development of LPA-induced macrophages. In humans, LPA mediates macrophage formation following similar pathways. These findings identify a critical role for LPA in regulating innate immune system.

Item Type: Article
Uncontrolled Keywords: LPA converts monocytes into macrophages. LPA mediates macrophage formation via Akt/mTor pathway; PPARg is a master regulator of LPA-derived macrophages.
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 09 Jan 2018 09:22
Last Modified: 09 Jan 2018 09:22
URI: http://eprints.manipal.edu/id/eprint/147765

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