Evaluation of the Aphrodisiac Potential of a Chemically Characterized Aqueous Extract of Tamarindus indica Pulp

Rai, Amita and Das, Snehashis and Rao, Mallikarjuna Chamallamudi and Nandakumar, Krishnadas and Gill, Meghna and Sumalatha, Suhani and Devkar, Raviraj Anand and Gourishetti, Karthik and Kumar, Nitesh (2018) Evaluation of the Aphrodisiac Potential of a Chemically Characterized Aqueous Extract of Tamarindus indica Pulp. Journal of Ethnopharmacology, 210. pp. 118-124. ISSN 0378-8741

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Abstract

Ethnopharmacological relevance: Tamarindus indica is an ingredient in the traditional aphrodisiac formulations in Africa and India. It is also a widely used food ingredient in other tropical countries.Aim of the study: The present study was aimed to evaluate the aphrodisiac potential and reproductive safety profile of aqueous extract of Tamarindus indica in male Wistar rats.Materials and methods: The aqueous extract was repared by maceration of pulp followed by reduction of volume in rotavapor under heat followed by freeze drying. The prepared extract was characterized for contents of total phenol, flavonoid, and saponin. It was also subjected to phytoconstituent analysis using GCMS. Further, the extract was evaluated for acute toxicity study. The aphrodisiac and reproductive toxicity potential were evaluated in animals after grouping them in four with six animals each namely, normal control, standard (Sildenafil citrate, 4 mg/kg p.o.) and extract of Tamarindus indica treated groups at two dose levels, 125 and 250 mg/kg p.o. The study was conducted for 54 days with daily once dosing of extract and standard. Equal number of females was grouped without treatment for evaluation of parameters of sexual desire (mount frequency and intromission frequency) and parameters of sexual arousal (mount latency and intromission latency). These parameters were evaluated on day 14, 28, 42 and 54. Animals were sacrificed on day 54, testes were removed and studied for histopathological changes.Results: The extract showed 6.6 mg gallic acid equivalent/g of total phenol, 2.3 mg catechin equivalent/g of flavonoid and 11.6% saponin. Forty chemical constituents were identified by GCMS analysis. In acute toxicity study, the extract was found to be safe till 2000 mg/kg p.o. Efficacy study showed significant (p < 0.05) improvement in parameters of sexual desire (mount frequency and intromission frequency) and parameters of sexual arousal on all observed days except mount frequency for 125 mg/kg on 42nd day and intromission frequency for both doses of tamarind compared to normal control. Improvements in these parameters were comparable to the standard drug. Histopathology study and sperm count suggested an increase in sperm production without any sign of toxicity in testis. Sperm motility significantly (p < 0.05) increased in the treatment groups that received extract at 250 mg/kg compared to normal control. Conclusion: Aqueous extract of Tamarindus indica possessed aphrodisiac activity together with spermatogenic potential

Item Type: Article
Uncontrolled Keywords: Tamarindus indica; Aphrodisiac; Sperm count; Sperm motility; Saponin
Subjects: Medicine > KMC Mangalore > Anatomy
Pharmacy > MCOPS Manipal > Pharmacognosy
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 09 Jan 2018 09:34
Last Modified: 09 Jan 2018 09:34
URI: http://eprints.manipal.edu/id/eprint/147776

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