Synthesis, Antimicrobial Evaluation and Docking Studies of Novel Quinoline Carboxamide analogs

Gaikwad, Kiran Narayan and Kini, Suvarna G and Saxena, Akashdeen and Martina, Suganthi and Ballal, Mamatha and Muhammad, Mubeen (2016) Synthesis, Antimicrobial Evaluation and Docking Studies of Novel Quinoline Carboxamide analogs. International Journal of Pharmaceutical Sciences Review and Research, 41 (2). pp. 344-348. ISSN 0976 – 044X

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Abstract

A series of twenty novel quinoline carboxamide analogues have been synthesized. Treatment of different anilines with quinoline carboxylic acid derivative was carried out to yield the desired product. A series of compounds from 1a-1t were synthesized,characterized by physical and spectral data and evaluated for their antimicrobial activity using disc plate method at 200μg/ml concentration using ciprofloxacin as standard which had initial zone of inhibition of 23mm. Compounds 1a, 1b, 1k to 1o gave promising activity against Aeromonas and compounds 1f to 1q and 1s and 1t were active against Enterococcus species. Docking studies were carried out to study the interaction of these analogues with the target Aeromonas hydrophila.

Item Type: Article
Uncontrolled Keywords: Quinoline; Carboxamide; Aniline; Disc-plate method; Antimicrobial; Ciprofloxacin; Aeromonas; Anterococcus
Subjects: Medicine > MMMC Manipal > Biochemistry
Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Library
Date Deposited: 10 Jan 2017 15:50
Last Modified: 10 Jan 2017 15:50
URI: http://eprints.manipal.edu/id/eprint/147967

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