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Optimization of a glucocorticoid encapsulated PLGA nanoparticles for inflammatory diseases

Acharya, Sriprasad and Guru, Bharath Raja (2016) Optimization of a glucocorticoid encapsulated PLGA nanoparticles for inflammatory diseases. In: Biotechnology and Biochemical Engineering, "Select Proceedings of ICACE 2015. Springer Singapore.

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Abstract

Steroids like glucocorticoids, assist in reducing internal inflammation due to their anti-inflammatory properties. A sustained release of these steroids will help reduce the severe side effects. In this present study, nanoparticles (NPs) of poly (D, L-lactide-co-glycolide) (PLGA) –50:50 were prepared by emulsification method, with Polyvinyl alcohol (Mol. Wt. 70-110 kDa) as the stabilizer. Prednisolone (glucocorticoid) was loaded into PLGA NPs by single emulsion solvent evaporation technique. The distributions of the size of PLGA NPs were in the range of 347 - 2354 nm. In an attempt to prepare a suitable drug delivery system, we formulated and optimized the prednisolone containing NPs by using factorial design method. The effect of different process variables, including the stabilizer, drug/polymer ratio and sonication time on the size of particles, zeta potential and the amount of loaded drug was investigated

Item Type: Book Section
Uncontrolled Keywords: Prednisolone, PLGA, nanoparticles, Drug loading, solvent evaporation, Factorial design
Subjects: Engineering > MIT Manipal > Biotechnology
Engineering > MIT Manipal > Chemical
Depositing User: MIT Library
Date Deposited: 14 Jan 2017 09:13
Last Modified: 14 Jan 2017 09:13
URI: http://eprints.manipal.edu/id/eprint/148117

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