Pharmacokinetic Potentiation of Mixed Organophosphate and Pyrethroid Poison Leading to Prolonged Delayed Neuropathy

Srinivasan, Meenakshi and Amin, Ruhul and Girish, T and Shivashankara, KN and Chandrashekar, UK (2016) Pharmacokinetic Potentiation of Mixed Organophosphate and Pyrethroid Poison Leading to Prolonged Delayed Neuropathy. Journal of Clinical and Diagnostic Research, 10 (11). pp. 1-2. ISSN 0973-709X

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Abstract

Organophosphate (OP) and mixed pesticide poisoning remains an important cause of hospital admission. Therefore, physician must be aware of atypical presentations of delayed neurological complications of poisoning by taking proper patient history. We report a case of a 23-year-old female who presented with high stepping gait and muscle wasting in hands. Patient history revealed consumption of approximately 4ml of mixed pesticide, consisting of 50% chlorpyrifos with synthetic pyrethroid, 5% cypermethrin. The prolonged and severe nature of delayed peripheral neuropathy, persisting at two years of follow-up, suggests that even small quantities of OP taken in combination with a pyrethroid can result in significant morbidity and is irreversible.

Item Type: Article
Uncontrolled Keywords: Chlorpyrifos; Cypermethrin; Mixed poisoning
Subjects: Medicine > KMC Manipal > Medicine
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Library
Date Deposited: 14 Jan 2017 15:45
Last Modified: 14 Jan 2017 15:45
URI: http://eprints.manipal.edu/id/eprint/148124

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