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Indices of Glucose Homeostasis in Cord Blood in Term and Preterm Newborns

Ahmad, Afzal and *, Rukmini M S and Yadav, Charu and Agarwal, Ashish and Manjrekar, Poornima and Hegde, Anupama (2016) Indices of Glucose Homeostasis in Cord Blood in Term and Preterm Newborns. Journal of Clinical Research in Pediatric Endocrinology, 8 (3). pp. 270-275. ISSN 13085727

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Abstract

Objective: According to the thrifty phenotype hypothesis, intrauterine malnutrition has a role in the etiology of type 2 diabetes. This study was planned to determine the early alterations in indices of glucose homeostasis (glucose, insulin, and cortisol) in term and preterm newborns and the correlations of glucose, insulin, and cortisol levels with insulin resistance indices. Methods: A descriptive study comprising 35 term and 35 preterm newborns was carried out from December 2013 to June 2015. Venous cord blood was collected and plasma glucose was analyzed by the glucose oxidase-peroxidase method in an auto analyzer. Serum insulin and cortisol levels were assessed by the enzymelinked immunosorbent assay. Homeostasis model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index and glucose insulin ratio were calculated to assess insulin resistance. The data on physical and metabolic parameters were analyzed using standard tests for statistical significance. Results: In term newborns, mean glucose and cortisol levels (83.6±17.4 mg/dL and 11.88±5.78 μg/dL, respectively) were significantly higher than those in preterm infants (70.4±15.8 mg/dL and 8.9±4.6 μg/dL, respectively). Insulin and HOMA-IR levels were found higher in preterm newborns (10.8±4.8 μIU/mL and 1.52±0.66, respectively) than in term newborns (7.9±2.7 μIU/mL and 1.19±0.29, respectively). Insulin was found to positively correlate with HOMA-IR, whereas cortisol was negatively correlated with HOMA-IR in both term and preterm newborns. Conclusion: Higher insulin levels and HOMA-IR values in the cord blood of preterm newborns support the theory of intrauterine origin of metabolic diseases.

Item Type: Article
Uncontrolled Keywords: Cord blood, cortisol, glucose, insulin, insulin resistance
Subjects: Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 18 Jan 2017 11:18
Last Modified: 18 Jan 2017 11:18
URI: http://eprints.manipal.edu/id/eprint/148162

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