Chauhan, Arunima and Boaz, Karen (2015) Proliferative Capacity of KCOT, Dentigerous Cyst and Ameloblastoma. International Journal of Dental and Health Sciences, 2 (5). pp. 1149-1158. ISSN 2348-5280

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Abstract

Aim: In view of the current designation of KCOT as benign cystic neoplasm, the aim of this study was to assess the proliferative activity of KCOT and compare the same with that of an acknowledged indolent odontogenic cyst (like dentigerous cyst) and an aggressive tumour (like ameloblastoma) using image analysis of AgNORs.Materials And Methods: Histological sections were prepared from formalin-fixed, paraffin-embedded tissue blocks of 15 cases each of KCOT, dentigerous cyst and conventional ameloblastoma and 10 cases of unicystic ameloblastoma to be stained with silver stain for visualization of AgNORs. The number of AgNORs per nucleus was counted manually whereas AgNOR area and perimeter were determined using computerized image analysis.Results:The results obtained were statistically analysed. The results obtained for mean AgNOR area and perimeter suggested the mean AgNOR area and perimeter to be unreliable parameters to assess the proliferative potential of the odontogenic lesions studied. The results obtained for mean AgNOR number suggested that mean AgNOR number is a reliable marker of the proliferative activity of a cell.Conclusion:Based AgNOR count of 55 archival samples, we conclude that KCOT is comparable to conventional ameloblastoma in its biological behaviour and behaves as an odontogenic tumour

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