Demonstration of Resolution of Amlodipine Induced Pedal Edema by Cilnidipine

Shetty, Kiran Kumar and Shetty, Ranjan K and Rao, Pragna and Deepak, * and Reddy, Sravan and Nayak, Vidya (2016) Demonstration of Resolution of Amlodipine Induced Pedal Edema by Cilnidipine. International Journal of Pharmaceutical Sciences Review and Research, 41 (1). pp. 229-233. ISSN 0976 – 044X

[img] PDF
1605 DisplayPdf.pdf - Published Version
Restricted to Registered users only

Download (830kB) | Request a copy


The aim of the study is to demonstrate the resolution of Amlodipine induced pedal edema by substitution of Cilnidipine with an adequate hypertension control. This was a prospective, Interventional study. Conducted at the tertiary care center in south India. A total number of 66 (n = 66) patients with essential hypertension with the amlodipine-induced edema of both genders, attending the outpatient department of medicine and cardiology, were included in the study. Amlodipine induced pedal edema was confirmed by various tests. After the Initial screening, amlodipine therapy was substituted to Cilnidipine with an efficacy equivalent dose. Clinical and biochemical parameters measured at the onset of the study and reassessed after 4 weeks of Cilnidipine therapy. At the end of the study, amlodipine-induced pedal edema was completely resolved in all the patients. There was a significant decrease in vanillyl mandelic acid (VMA) and (P <0.001), which is end metabolite of catecholamine. There was a substantial reduction in bilateral ankle circumference, Body weight and BMI (P <0.001). There was a significant decrease in blood pressure and pulse rate (P <0.001).Cilnidipine therapy leads to a complete resolution of amlodipine-induced edema, along with a better hypertension control.Cilnidipine is decreasing the release of catecholamine by inhibiting N-type of calcium channels at the neuronal terminal. Cilnidipine is a suitable alternative antihypertensive medication for patients with the amlodipine-induced edema.

Item Type: Article
Uncontrolled Keywords: Amlodipine; Cilnidipine; Vanillyl Mandelic Acid; Pedal Edema
Subjects: Allied Health > MCOAHS Manipal > Cardiology
Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Cardiology
Depositing User: KMC Library
Date Deposited: 24 Jan 2017 10:26
Last Modified: 24 Jan 2017 10:26

Actions (login required)

View Item View Item