Photoacoustic Spectroscopy based Investigatory Approach to Discriminate Breast Cancer from Normal: A Pilot Study

Priya, Mallika and Rao, Satish BS and Chandra, Subhash and Ray, Satadru and Mathew, Stanley and Datta, Anirbit and Nayak, Subramanya G and Mahato, Krishna Kishore (2016) Photoacoustic Spectroscopy based Investigatory Approach to Discriminate Breast Cancer from Normal: A Pilot Study. Proceedings of SPIE-The International Society for Optical Engineering, 9689 (968943). pp. 1-5. ISSN 1996-756X

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In spite of many efforts for early detection of breast cancer, there is still lack of technology for immediate implementation. In the present study, the potential photoacoustic spectroscopy was evaluated in discriminating breast cancer from normal, involving blood serum samples seeking early detection. Three photoacoustic spectra in time domain were recorded from each of 20 normal and 20 malignant samples at 281nm pulsed laser excitations and a total of 120 spectra were generated. The time domain spectra were then Fast Fourier Transformed into frequency domain and 116.5625 - 206.875 kHz region was selected for further analysis using a combinational approach of wavelet, PCA and logistic regression. Initially, wavelet analysis was performed on the FFT data and seven features (mean, median, area under the curve, variance, standard deviation, skewness and kurtosis) from each were extracted. PCA was then performed on the feature matrix (7x120) for discriminating malignant samples from the normal by plotting a decision boundary using logistic regression analysis. The unsupervised mode of classification used in the present study yielded specificity and sensitivity values of 100% in each respectively with a ROC - AUC value of 1. The results obtained have clearly demonstrated the capability of photoacoustic spectroscopy in discriminating cancer from the normal, suggesting its possible clinical implications

Item Type: Article
Subjects: Engineering > MIT Manipal > Electronics and Communication
Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Surgery
Medicine > KMC Manipal > Surgical Oncology
Depositing User: KMC Library
Date Deposited: 23 Jan 2017 13:54
Last Modified: 23 Jan 2017 13:54

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