Shenoy, Gautham G (2017) ‘One-pot’ organocatalyzed enantioselective synthesis of highly functionalized 3,4,5,6-tetrasubstituted dihydropyrans by sequential Knoevenagel condensation/Michael addition and hemiacetalization. Tetrahedron: Asymmetry, 28 (1). pp. 153-161. ISSN 0957-4166
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Abstract
An organocatalytic ‘one-pot’ synthesis of highly functionalized 3,4,5,6-tetrasubstituted dihydropyrans has been developed. Excellent enantio- and diastereo selectivity with good yields are some of the salient features of this methodology. This reaction takes advantage of proline based catalysts and follows stepwise sequential transformations including Knoevenagel condensation–Michael addition–hemiacetalization towards the synthesis of complex dihydropyranol framework.
Item Type: | Article |
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Subjects: | Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry |
Depositing User: | KMC Library |
Date Deposited: | 24 Jan 2017 10:34 |
Last Modified: | 24 Jan 2017 10:34 |
URI: | http://eprints.manipal.edu/id/eprint/148196 |
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