Learning epigenetic regulation from mycobacteria

Sharma, Garima and Yaseen, Imtiyaz (2016) Learning epigenetic regulation from mycobacteria. Microbial Cell, 3 (2). pp. 92-93.

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In a eukaryotic cell, the transcriptional fate of a gene is determined by the profile of the epigenetic modifications it is associated with and the conformation it adopts within the chromatin. Therefore, the function that a cell performs is dictated by the sum total of the chromatin organization and the associated epigenetic modifications of each individual gene in the genome (epigenome). As the function of a cell during development and differentiation is determined by its microenvironment, any factor that can alter this microenvironment should be able to alter the epigenome of a cell. In the study published in Nature Communications (Yaseen [2015] Nature Communications 6:8922 doi: 10.1038/ncomms9922), we show that pathogenic Mycobacterium tuberculosis has evolved strategies to exploit this pliability of the host epigenome for its own survival. We describe the identification of a methyltransferase from M. tuberculosis that functions to modulate the host epigenome by methylating a novel, non-canonical arginine, H3R42 in histone H3. In another study, we showed that the mycobacterial protein Rv2966c methylates cytosines present in non-CpG context within host genomic DNA upon infection. Proteins with ability to directly methylate host histones H3 at a novel lysine residue (H3K14) has also been identified from Legionella pnemophilia (RomA). All these studies indicate the use of non-canonical epigenetic mechanisms by pathogenic bacteria to hijack the host transcriptional machinery.

Item Type: Article
Uncontrolled Keywords: Rv1988; Mycobacterium tuberculosis; histone arginine methylation; DNA methylation; epigenetics; Rv2966c; H3R42.
Subjects: Research > Research Center - Health Sciences
Depositing User: KMC Library
Date Deposited: 24 Jan 2017 10:51
Last Modified: 24 Jan 2017 10:51
URI: http://eprints.manipal.edu/id/eprint/148198

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