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Protein Profile Study of Breast Cancer Tissues Using HPLC-LIF- A Pilot Study

Menon, Suraj and Sujatha, * and Kumar, Kalyan K and Kurien, Jacob and Krishnanan, BR and Mahato, KK and George, Sajan D and Kartha, VB and Santhosh, C (2007) Protein Profile Study of Breast Cancer Tissues Using HPLC-LIF- A Pilot Study. Proc. of SPIE.

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Abstract

Proteomics based techniques are rapidly emerging as alternative techniques to conventional histo-pathological methods for detection and diagnosis of cancers. Tumor markers are of considerable importance in the study of various cancers. A study of various changes in the protein profile associated with breast cancer will facilitate a better understanding of the various dynamic changes associated with the disease. In our study we have used High Performance Liquid Chromatography coupled with highly sensitive Laser Induced Fluorescence for recording the protein profiles of breast tissue homogenates. The protein profiles were recorded from pathologically certified normal as well as malignant breast tissue samples. The recorded protein profiles were studied by using Principal Component Analysis. Good discrimination of normal, benign and malignant samples was achieved in this pilot study.

Item Type: Article
Uncontrolled Keywords: Breast cancer, HPLC-LIF, Protein profiles, PCA.
Subjects: Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Pathology
Medicine > KMC Manipal > Surgical Oncology
Depositing User: KMC Manipal
Date Deposited: 07 Oct 2011 04:21
Last Modified: 07 Oct 2011 04:21
URI: http://eprints.manipal.edu/id/eprint/1482

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