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Metformin Attenuates Cognitive Deficits in Experimentally Induced Alzheimer’s Disease

Dash, Devasrita and Chogtu, Bharti and Bairy, KL (2017) Metformin Attenuates Cognitive Deficits in Experimentally Induced Alzheimer’s Disease. Journal of Global Pharma Technology, 1 (9). pp. 8-12. ISSN 0975 -8542

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Abstract

A study was undertaken to evaluate the effect of metformin on learning memory in experimentally induced Alzheimer’s disease in Wistar rats. A total of 30 Wistar rats were divided in to five groups of six rats each. Group 1 served as control. In Group 2,3 and 4 Alzheimer’s disease was induced by administering aluminum chloride (17 mg/kg) orally to the animals for a period of 4 weeks once daily. Group 1and 2 received distilled water, group 3 received rivastigmine (0.3mg/kg) and group 4 and five received metformin 100mg/kg. All the rats were subjected to passive avoidance test. At the end of the experiment the rats were sacrificed and brain acetylcholinesterase level was estimated.Administration of aluminium chloride resulted in poor learning and memory and this was significantly reversed by rivastigmine and metformin. In conclusion, the memory impairment induced by aluminum chloride was revered significantly by both rivastigmine and metformin.

Item Type: Article
Uncontrolled Keywords: Alzheimer’s disease; Metformin; Rivastigmine; Passive avoidance test; Acetylcholinesterase
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 02 Feb 2017 09:00
Last Modified: 02 Feb 2017 09:00
URI: http://eprints.manipal.edu/id/eprint/148249

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