Praharaj, Samir Kumar (2016) Very Low Dose Amitriptyline for Clozapine-Associated Sialorrhea. Current Drug Safety, 11 (3). pp. 262-263. ISSN 1574-8863
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Abstract
Clozapine is an antipsychotic drug recommended for resistant schizophrenia, but its widespread use is limited by adverse effects. Sialorrhea is a common and troublesome adverse effect seen with clozapine which leads to poor compliance. Several treatment strategies are advocated, no single treatment is considered superior. Amitriptyline, a tricyclic antidepressant, has been found to be useful for clozapine-associated sialorrhea at 87-100 mg per day. We report the effect of very low dose amitriptyline (10 mg per day) in a patient with clozapine-associated sialorrhea. There was rapid and complete resolution of sialorrhea after three days without any emergent adverse effect.
Item Type: | Article |
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Uncontrolled Keywords: | Clozapine; Amitriptyline; Sialorrhea; Hypersalivation |
Subjects: | Medicine > KMC Manipal > Psychiatry |
Depositing User: | KMC Library |
Date Deposited: | 03 Feb 2017 10:47 |
Last Modified: | 03 Feb 2017 10:47 |
URI: | http://eprints.manipal.edu/id/eprint/148266 |
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