Somasundaram, DB and Manokaran, K and Selvanesan, BC and Bhaskaran, RS (2016) Impact of di-(2-ethylhexyl) Phthalate on the Uterus of Adult Wistar Rats. Human and Experimental Toxicology. pp. 1-8. ISSN 0960-3271
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Abstract
Di-(2-ethylhexyl) phthalate (DEHP) is the most common plasticizer used in polyvinyl chloride-based plastics.DEHP is not covalently bound to the plastics and is easily released to the environment, resulting in human exposure. In this study, the adult rats were exposed to DEHP and its effects on the uterus was evaluated.Healthy adult female rats were treated with DEHP orally (with dose level 0, 1, 10, and 100 mg/kg body weight/day) for 30 days. No significant changes in the body weight and wet uterine weight were observed.Ovarian hormones and their receptor levels in the uterus were increased. Histological studies exhibited the structural abnormalities such as decrease in diameter, thinning of the layers and disruption in the glandular epithelium.
Item Type: | Article |
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Uncontrolled Keywords: | DEHP; Estrogen receptors; Progesterone receptorsP PPAR; Uterus |
Subjects: | Allied Health > MCOAHS Manipal > Medical Laboratory Tech |
Depositing User: | KMC Library |
Date Deposited: | 07 Feb 2017 14:38 |
Last Modified: | 07 Feb 2017 14:38 |
URI: | http://eprints.manipal.edu/id/eprint/148290 |
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