An Evaluation Of The Wound Healing And Anti-Microbial Property Of The Tincture Of Lantana Camara

Kumar, Vinay and Uma, VK and Kumar, Ravi and Vandana, KE and Nayak, Veena (2015) An Evaluation Of The Wound Healing And Anti-Microbial Property Of The Tincture Of Lantana Camara. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (5). pp. 313-316. ISSN 0975-1491

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Abstract

Objective: Lantana camaraL (L. c) has been known for its anti-bacterial activity since quite some time in its various extracts and pharmacological preparations. In view of this, we plan to study and compare the wound healing property of tincture of L. cin surgically induced wound in animal models with tincture of iodine (I2).Methods: An herbal tincture was developed from stems of L. cin concentrations of 20%, 40%, alcohol in tincture was followed as mentioned in IP, tested against tincture I2 in same aged different groups of rats under incision and excision models, also with commonly wound infecting bacteria like S. aureus, E. coli, E. fecalis, P. aeruginosa. Wounds were induced surgically under anaesthesia. Excised rats were observed for wound contraction and epithelialisation. On 7th day, incised rats were subjected to wound dehiscence test. Tissue biopsy took on day 5, 14 and21 for histopathological studies.Results: Both test groups were found statistically significant against standard with P<0.05 and with mean epithelialisation day value 11±1.02 in the excision model and P<0.05 between the groups in incision model depicting 20% tincture as better with a mean value of 366.67±47.2. Histologically 40% tincture was found non-inferior against standard. Tincture was active against mentioned microbes in various dilutions.Conclusion: Tincture L. c was non-inferior to iodine. Further studies with concentrated extracts of L. cmay reveal its accelerated healing and better anti-microbial competency so that it can be developed for clinical practice.

Item Type: Article
Uncontrolled Keywords: Herbal tincture; Tincture and wounds; Wound healing; Lantana camara; Tincture of iodine; Excision-incision wound model; Anti-bacterial activity
Subjects: Medicine > KMC Manipal > Microbiology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 20 Mar 2017 03:46
Last Modified: 20 Mar 2017 03:46
URI: http://eprints.manipal.edu/id/eprint/148521

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