Design and characterization of Valsartan Co-Crystals to improve its aqueous solubility and dissolution behavior

Thomas, Jino Elsa and Nayak, Usha Y and Jagadish, PC and Koteshwara, KB (2017) Design and characterization of Valsartan Co-Crystals to improve its aqueous solubility and dissolution behavior. Research Journal of Pharmacy and Technology, 10 (1). pp. 26-30. ISSN 0974-3618

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Abstract

The aim of the work was to prepare co-crystals of valsartan, a BCS Class II drug to enhance its aqueous solubility and bioavailability. The solvent evaporation method was used to prepare co-crystals by using different co-formers and varying the drug to co-former molar ratios. Succinic acid was found to be suitable co-former to prepare co-crystals with good physico-chemical properties. The solid state characterization of co-crystals were studied by FTIR, DSC and XRD. The co-crystals were evaluated for the saturation solubility and dissolution studies. Solubility study in distilled water indicated low solubility of valsartan (198.5 μg/ml), there was 2.6 fold increase in the solubility of co-crystals prepared using succinic acid, with 1:5 drug to co-former ratio (520.6 μg/ml). Solid state characterizations indicated there was no change in the chemical nature of the co-crystals compared to pure drug. Presence of crystalline co-former induced crystallinity to the developed co-crystals. Thus developed co-crystals were found to be suitable alternative to increase the solubility and dissolution rate of valsartan.

Item Type: Article
Uncontrolled Keywords: Valsartan; co-crystals; solvent evaporation; co-formers; succinic acid; bioavailability.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Library
Date Deposited: 27 Mar 2017 04:12
Last Modified: 27 Mar 2017 04:12
URI: http://eprints.manipal.edu/id/eprint/148569

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