Comparison of Cord Blood Lipid Profile in Preterm Small for Gestational Age and Appropriate for Gestational Age Newborns

katragadda, Tejasree and *, Rajesh S M and Shetty, Subodh and Baliga, Shantharam B (2017) Comparison of Cord Blood Lipid Profile in Preterm Small for Gestational Age and Appropriate for Gestational Age Newborns. Journal of Clinical and Diagnostic Research, 11 (1). SC05-SC07. ISSN 0973-709X

[img] PDF
Journal of Clinical and Diagnostic Research -1.pdf - Published Version
Restricted to Registered users only

Download (64kB) | Request a copy

Abstract

Introduction: Coronary heart disease is one of the major causes of morbidity and mortality in current era. The roots of this epidemic have been traced to as early as foetal life by foetal origin hypothesis. There are a few studies which have compared the cord blood lipid profile of preterm and term babies and thereby leading a path to primordial prevention of chronic diseases. Aim: To study cord blood lipid profile of preterm appropriate for gestational age and preterm small for gestational age neonates and compare atherogenic index of both groups. Materials and Methods: This cross-sectional study was conducted in 109 preterm infants. Cord blood samples were collected from placental side of umbilical cord at birth and analyzed for lipid profile which includes serum cholesterol, triglycerides, Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and apolipoproteins which include ApoA1, Apo B. Results: Preterm Small for Gestational Age (SGA) neonates had statistically significant higher values of triglycerides, Apo B and atherogenic index compared to preterm Appropriate for Gestational Age (AGA) neonates. Other measured lipid levels were not statistically significant, though the values were higher than reference ranges for term babies. Conclusion: Prematurity as a factor associated with a more atherogenic lipid profile is re-affirmed and SGA as an additional risk factor has been proven giving scope for future research and primordial prevention.

Item Type: Article
Uncontrolled Keywords: Apolipoprotein B, Atherogenic index, Preterm neonate
Subjects: Medicine > KMC Mangalore > Paediatrics
Depositing User: KMCMLR User
Date Deposited: 30 Mar 2017 06:26
Last Modified: 30 Mar 2017 06:26
URI: http://eprints.manipal.edu/id/eprint/148622

Actions (login required)

View Item View Item