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Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy

D’souza, Jyothi M. P. and *, Sindhu Harish and Pai, Vinitha Ramanath and *, Chitra Shriyan (2017) Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy. Indian Journal of Clinical Biochemistry, 32 (2). pp. 200-206. ISSN 0970-1915

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Abstract

Protein oxidation has been demonstrated in preeclampsia, but this finding has not been established in other hypertensive disorders in pregnancy (HDP). The present study comparatively evaluated ischemia modified albumin (IMA) and advanced oxidation protein products (AOPP) in different HDP and investigated their association with total antioxidant activity (AOA) and total thiols. There was a significant increase in AOPP and IMA, a significant decrease in AOA, total thiols and albumin in every HDP compared to controls. Among HDP groups, eclampsia patients showed more significant change in each of the parameter. IMA and AOPP were negatively associated with AOA in every HDP and with total thiols only in eclampsia. The present study supports the hypothesis of oxidative stress, as evidenced by increased protein oxidation, decreased antioxidant status and significant negative association between protein oxidation and AOA in every HDP. The imbalance of prooxidants and antioxidants was further augmented in eclampsia.

Item Type: Article
Uncontrolled Keywords: Protein oxidation · Hypertensive disorders of pregnancy · Ischemia modified albumin · Advanced oxidation protein products · Total antioxidant activity · Total thiols
Subjects: Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 08 Apr 2017 06:05
Last Modified: 08 Apr 2017 06:05
URI: http://eprints.manipal.edu/id/eprint/148676

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