A Pilot Study on Vitamin D and Respiratory Diseases in Southern Part of India

Shenoy, Vijetha Belle and Prabhu, Krishnananda (2017) A Pilot Study on Vitamin D and Respiratory Diseases in Southern Part of India. International Journal of Current Research and Review, 9 (7). pp. 15-18. ISSN 0975-5241

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Background: Over the past decade, interest has grown in the role of vitamin D in many nonskeletal medical conditions,such as cancer, diabetes mellitus, and cardiovascular diseases including respiratory infection. Emerging evidence indicates that vitamin D-mediated innate immunity is important in host defenses against respiratory tract pathogens. There are few researches linking vitamin D to various immune-related conditions, including asthma, allergic rhinitis, although the pattern of this relationship is still yet to establish. This study was done to understand the role of vitamin D levels in patients with respiratory tract infection in the southern part of India.Materials and Methods: After obtaining ethical clearance from the institutional ethics committee retrospective study was conducted. A total of 125 Patients with respiratory complaints like bronchial asthma, chronic obstructive pulmonary disease, and allergic rhinitis were included.100 healthy volunteers were included as a control. Total serum vitamin D assay was measured by ECLIA method. Serum IgE levels were measured using COBAS 6001 analyzer. Statistical analysis was done using SPSS 16.0 version.Results: Vitamin D level was highly significantly lower(p <0.01) in the respiratory diseases group compared with the control group, and the total IgE level was highly significantly higher in the asthmatic groups compared with the control group.Conclusion: Deficiency of Vitamin D levels may predispose to respiratory infections. Supplementation with vitamin D, exposure to sun light and increased physical activity may decrease the predisposition to respiratory tract infection.

Item Type: Article
Uncontrolled Keywords: Vitamin D; Respiratory tract infections; IgE
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Library
Date Deposited: 13 Apr 2017 06:16
Last Modified: 13 Apr 2017 06:16
URI: http://eprints.manipal.edu/id/eprint/148698

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