Cervical cytological abnormalities and human papilloma virus infection in women infected with HIV in Southern India

Thunga, Suchitra and Andrews, Anusmitha and *, John T Ramapuram and *, Kapaettu Satyamoorthy and Kini, Hema and *, Unnikrishnan B and Adhikari, Prabha and Singh, Prakhar and Kabekkodu, Shama Prasada and Bhat, Samatha and Kadam, Anagha and Shetty, Avinash K (2016) Cervical cytological abnormalities and human papilloma virus infection in women infected with HIV in Southern India. Journal of Obstetrics and Gynaecology Research, 42 (16). pp. 1822-1828. ISSN 13418076

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Abstract

Aim: The aim of this study was to examine the association between CD4 count, human papilloma virus (HPV) infection, and the risk of cervical intraepithelial neoplasia among HIV-infected women. Methods: A cross-sectional study was conducted among 104 HIV-infected women attending an antiretroviral therapy clinic. They underwent Pap smear and cervical HPV DNA testing. Results: The overall prevalence of HPV infection was 57.7%. HPV 16 was the commonest genotype found (38.5%); HPV 16 and 18 put together contributed to 73.3% of HPV infection; 27.5% of HIV-infected women had squamous cell abnormalities. Cervical intraepithelial neoplasia was less likely among women with CD4 count > 500/mm3 (12%) and in those without opportunistic infections (17.8%). The prevalence of high-risk HPV infection was higher in women with high-grade squamous intraepithelial lesions or greater lesions (85.7%) as compared to women with normal cytology (52.1%). Conclusion: The high prevalence of HPV infection and cervical intraepithelial neoplasia in HIV-infected women warrants the need for regular Pap smear screening in these women and routine HPV vaccination for adolescents to reduce the burden of cervical cancer in India. Key words: cervical intraepithelial neoplasia, HIV, human papilloma virus, Pap smear

Item Type: Article
Uncontrolled Keywords: cervical intraepithelial neoplasia, HIV, human papilloma virus, Pap smear.
Subjects: Life Sciences > MLSC Manipal
Medicine > KMC Mangalore > Obstetrics & Gynaecology
Medicine > KMC Mangalore > Pathology
Medicine > KMC Mangalore > Community Medicine
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 19 Apr 2017 06:50
Last Modified: 19 Apr 2017 06:50
URI: http://eprints.manipal.edu/id/eprint/148732

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