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Epigenetics in cancer: Fundamentals and beyond

Biswas, Subhankar and Rao, Mallikarjuna C (2017) Epigenetics in cancer: Fundamentals and beyond. Pharmacology & Therapeutics, 173 (1). pp. 118-134. ISSN 0163-7258

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Abstract

Activation of oncogenes or the deactivation of tumor suppressor genes has long been established as the fundamental mechanism leading towards carcinogenesis. Although this age old axiom is vastly accurate, thorough study over the last 15 years has given us unprecedented information on the involvement of epigenetic in cancer. Various biochemical pathways that are essential towards tumorigenesis are regulated by the epigenetic phenomenons like remodeling of nucleosome by histone modifications, DNAmethylation andmiRNA mediated targeting of various genes.Moreover the presence of mutations in the genes controlling the epigenetic players has further strengthened the association of epigenetics in cancer. This merger has opened up newer avenues for targeted anti-cancer drug therapywith numerous pharmaceutical industries focusing on expanding their research and development pipelinewith epigenetic drugs. The information provided here elaborates the elementary phenomena of the various epigenetic regulators and discusses their alteration associatedwith the development of cancer.We also highlight the recent developments in epigenetic drugs combining preclinical and clinical data to signify this evolving field in cancer research.

Item Type: Article
Uncontrolled Keywords: Epigenetics; cancer; histones; DNA methylation; miRNA; epigenetic drugs.
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 02 May 2017 10:56
Last Modified: 02 May 2017 10:56
URI: http://eprints.manipal.edu/id/eprint/148775

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