Ali, Aamir (2017) Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family. Journal of Biosciences, 42 (1). pp. 155-159. ISSN 0250-5991
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Abstract
WD repeat containing protein 5 (WDR5), Retinoblastoma Binding Protein 5 (RbBP5), Absent-Small-Homeotic-2- Like protein (ASH2L), and Dumpy-30 (Dpy30) have been reported to be the integral and shared components of all the SET1 family of histone 3 lysine 4 histone methyltransferase (HMT) complexes. Collectively called the WRAD complex, these proteins are pivotal to the HMT activity of the SET1 complexes. Recent reports highlight the novel non-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation and gene expression. In this review, we examine the diversity in emerging transcription-independent functions of WRAD.
Item Type: | Article |
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Uncontrolled Keywords: | Cell cycle regulation; SET1 family; transcription; WRAD. |
Subjects: | Research > Research Center - Health Sciences |
Depositing User: | KMC Manipal |
Date Deposited: | 25 May 2017 03:41 |
Last Modified: | 25 May 2017 03:41 |
URI: | http://eprints.manipal.edu/id/eprint/148949 |
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