MU Digital Repository
Logo

Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family

Ali, Aamir (2017) Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family. Journal of Biosciences, 42 (1). pp. 155-159. ISSN 0250-5991

[img] PDF
J Biosci 2017 Ma- ;42(1)- 155-159.pdf - Published Version
Restricted to Registered users only

Download (250kB) | Request a copy

Abstract

WD repeat containing protein 5 (WDR5), Retinoblastoma Binding Protein 5 (RbBP5), Absent-Small-Homeotic-2- Like protein (ASH2L), and Dumpy-30 (Dpy30) have been reported to be the integral and shared components of all the SET1 family of histone 3 lysine 4 histone methyltransferase (HMT) complexes. Collectively called the WRAD complex, these proteins are pivotal to the HMT activity of the SET1 complexes. Recent reports highlight the novel non-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation and gene expression. In this review, we examine the diversity in emerging transcription-independent functions of WRAD.

Item Type: Article
Uncontrolled Keywords: Cell cycle regulation; SET1 family; transcription; WRAD.
Subjects: Research > Research Center - Health Sciences
Depositing User: KMC Manipal
Date Deposited: 25 May 2017 03:41
Last Modified: 25 May 2017 03:41
URI: http://eprints.manipal.edu/id/eprint/148949

Actions (login required)

View Item View Item