What is it really? Anti-G or Anti-D plus Anti-C: Clinical significance in antenatal mothers

Das, Soumya and Shastry, Shamee and Murugesan, Mohandoss and Baliga, Poornima (2017) What is it really? Anti-G or Anti-D plus Anti-C: Clinical significance in antenatal mothers. Indian Journal of Hematology and Blood Transfusion, 33 (2). pp. 259-263. ISSN 0971-4502

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G antigen of Rh blood group system is present either along with D and/or C positive red cells. Hence, [serologically anti-G presents with the similar picture as that of multiple antibodies (anti-D + anti-C). Differentiating them is important as anti-D + anti-C causes severe hemolytic disease of the fetus and newborn than anti-G. In pregnancies with anti-G alone, alloimmunization due to D antigen could be prevented by prophylactic administration of RhIg. Differentiating between anti-D + C from anti-G in alloimmunized pregnant mothers becomes essential. Sera from antenatal mothers, whose antibody identification by 11-cell panel gave a pattern for anti-D and anti-C were selected. Extended phenotyping for Rh system was performed for these antenatal cases. Differential adsorption and elution testing using R2R2 cells initially and r’r cells subsequently were performed to distinguish anit-G from anti-D + anti-C. Antibody titers of these antibodies were determined and their clinical outcome in the newborn was followed. A pattern suggestive of anti D and anti C on antibody identification were observed in six antenatal cases. On further workup 50 % of them confirmed to have anti G. Antibody titers of anti-G and anti-C were lower than that of Anti-D. All newborns were sensitized in vivo and the antibody specificity in them were confirmed with elution studies. The mothers who had only anti-G were subsequently administered with an appropriate dose of RhIg.Differential adsorption and elution studies help in identifying anti-G and distinguishing it from anti-D plus anti-C, thus helping in better patient management.

Item Type: Article
Uncontrolled Keywords: Anti-G; Differential adsorption and elution; Antenatal.
Subjects: Medicine > KMC Manipal > Pathology
Depositing User: KMC Library
Date Deposited: 02 Jun 2017 11:13
Last Modified: 02 Jun 2017 11:13
URI: http://eprints.manipal.edu/id/eprint/148966

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