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Triple combination therapy and drug cycling—Tangential strategies for countering artemisinin resistance

Bhattacharjee, Dipanjan and Shivaprakash, G and Ommurugan, Balaji (2017) Triple combination therapy and drug cycling—Tangential strategies for countering artemisinin resistance. Current Infectious Disease Reports, 19 (7). pp. 1-7. ISSN 1523-3847

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Abstract

Purpose of Review This review attempts to understand the reasons for the successes and failures of the two novel strategies that have slowly begun to emerge as potential counters for anti-malarial drug resistance—“Triple Combination Therapy” and “Drug Cycling.” Recent Findings Recent reports have suggested that increasing the heterogeneity within the parasite’s environment, both at an individual and the population level, may help raise the probabilistic barrier of development of resistance in the parasite. The encouraging results following the implementation of a few experimental triple combination therapies like atovaquone–proguanil–artesunate along with the reemergence of chloroquine sensitive Plasmodium falciparum parasites in the sub-Saharan African nations have re-kindled mankind’s hope of curbing anti-malarial drug resistance.

Item Type: Article
Uncontrolled Keywords: Drug resistance; combination therapy; environmental heterogeneity; malaria; chloroquine renaissance.
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 08 Jun 2017 11:17
Last Modified: 08 Jun 2017 11:17
URI: http://eprints.manipal.edu/id/eprint/149018

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