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Hypoglycaemic activity of a polyherbal product in alloxan induced diabetic rats

*, Rathnakar U.P and *, Hashim Shaukatali Kaderbhai and *, Sudhakar Pemminatti and Shenoy, Ashok and *, Gopalakrishna H.N and *, Nandita and *, Farsana and *, Siddique (2011) Hypoglycaemic activity of a polyherbal product in alloxan induced diabetic rats. Drug Invention Today, 3 (3). pp. 1-2.

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Abstract

Background: Ayurveda, an ancient Indian system of medicine, mentions several plants that are useful in the correction of metabolic disorders such as diabetes mellitus. Plants have been exemplary source of drugs in the treatment of diabetes mellitus [DM]. Many of the currently available drugs have been directly or indirectly derived from them. In spite of being hundreds of claimants none have gained enough momentum in clinical practice as most of them lack scientific validation. YXK12 is a commercially available polyherbal product recently introduced in the market and manufacturers claim the product to have anti diabetic properties. This study was undertaken to evaluate the hypoglycaemic effect of this drug in Alloxan induced diabetic rats. Materials and methods: Alloxan monohydrate is used to induce diabetes mellitus in Wistar rats. Hypoglycemic effect of two doses of the drug YXK12 is evaluated in these rats and the results are compared to the effects of a placebo and the standard hypoglycaemic drug Glibenclamide. Results: Blood glucose lowering effect of YXK12 in the higher dose of 2000mg/kg was found statistically significant [p=0.001]. Lower dose of 1000mg.kg did not show statistically significant hypoglycaemic effect when compared to placebo control. Conclusion: The dose which has produced hypoglycaemic effect in rats is equivalent to the highest doses of the product recommended for patients of diabetes mellitus. This dose [2000mg/kg in rats] if converted to human dose is equivalent to highest human dose recommended. As lower doses have not demonstrated any hypoglycemic activity, lower doses in humans needs to be evaluated.

Item Type: Article
Uncontrolled Keywords: Diabetic, Alloxan, Polyherbal, Diabetic
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 13 Oct 2011 11:09
Last Modified: 18 Oct 2011 06:44
URI: http://eprints.manipal.edu/id/eprint/1492

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