Downregulation of s100 calcium binding protein a9 in esophageal squamous cell carcinoma

Sathe, Gajanan and Chavan, Sandip (2015) Downregulation of s100 calcium binding protein a9 in esophageal squamous cell carcinoma. Scientific World Journal, 2015. pp. 1-10.

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Abstract

The development of esophageal squamous cell carcinoma (ESCC) is poorly understood and the major regulatory molecules involved in the process of tumorigenesis have not yet been identified. We had previously employed a quantitative proteomic approach to identify differentially expressed proteins in ESCC tumors. A total of 238 differentially expressed proteins were identified in that study including S100 calcium binding protein A9 (S100A9) as one of the major downregulated proteins. In the present study, we carried out immunohistochemical validation of S100A9 in a large cohort of ESCC patients to determine the expression and subcellular localization of S100A9 in tumors and adjacent normal esophageal epithelia. Downregulation of S100A9 was observed in 67% (

Item Type: Article
Subjects: Research > Research Center - Health Sciences
Depositing User: KMC Library
Date Deposited: 12 Jul 2017 03:49
Last Modified: 12 Jul 2017 04:08
URI: http://eprints.manipal.edu/id/eprint/149322

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