Development and validation of a simple uv-spectroscopic method for the estimate metoprolol tartrate in bulk and tablet formulation

Chandra, Shishir and Sushmitha, Gude Sai and Muddukrishna, BS and Vasantharaju, SG (2017) Development and validation of a simple uv-spectroscopic method for the estimate metoprolol tartrate in bulk and tablet formulation. Journal of Global Pharma Technology, 7 (9). pp. 12-17. ISSN 0975-8542

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Abstract

Objective: UV-Spectroscopic method was developed and validated for quantitative determination of metoprolol tartrate. Method: The absorption maxima of metoprolol tartrate were found to be 223nm by using methanol as solvent. Results: The linearity range for metoprolol tartrate was 7-22μg/ml with correlation coefficient (r2) value 0.9982. The method was said to be accurate with 100% recovery and precise, robust as the %RSD was below 2. Metolar-50 marketed formulation was considered as test and assay was carried out. Assay was found to be 98.73%. Conclusion: So, a novel, simple and sensitive method was developed for assay of metoprolol tartrate and validated according to ICH Q2R1 guidelines.

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