Chandra, Shishir and Sushmitha, Gude Sai and Muddukrishna, BS and Vasantharaju, SG (2017) Development and validation of a simple uv-spectroscopic method for the estimate metoprolol tartrate in bulk and tablet formulation. Journal of Global Pharma Technology, 7 (9). pp. 12-17. ISSN 0975-8542
![[img]](http://eprints.manipal.edu/style/images/fileicons/application_pdf.png) |
PDF
00002889.pdf - Published Version Restricted to Registered users only Download (478kB) | Request a copy |
Abstract
Objective: UV-Spectroscopic method was developed and validated for quantitative determination of metoprolol tartrate. Method: The absorption maxima of metoprolol tartrate were found to be 223nm by using methanol as solvent. Results: The linearity range for metoprolol tartrate was 7-22μg/ml with correlation coefficient (r2) value 0.9982. The method was said to be accurate with 100% recovery and precise, robust as the %RSD was below 2. Metolar-50 marketed formulation was considered as test and assay was carried out. Assay was found to be 98.73%. Conclusion: So, a novel, simple and sensitive method was developed for assay of metoprolol tartrate and validated according to ICH Q2R1 guidelines.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Spectroscopic; Metoprolol tartrate; Absorption maxima; Assay. |
| Subjects: | Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance |
| Depositing User: | KMC Library |
| Date Deposited: | 13 Jul 2017 04:03 |
| Last Modified: | 13 Jul 2017 04:03 |
| URI: | http://eprints.manipal.edu/id/eprint/149345 |
Actions (login required)
 |
View Item |